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Association of MMP but not TIMP-1 gene polymorphisms with recurrent aphthous stomatitis

J A Karasneh1, M E Bani-Hani, A M Alkhateeb

  • 1Department of Oral Medicine and Oral Surgery, Jordan University of Science and Technology (JUST), Irbid, Jordan.

Oral Diseases
|October 15, 2013
PubMed
Abstract

Insights

Genetic variations in MMP-9 are linked to recurrent aphthous stomatitis (RAS) susceptibility. Specifically, the MMP-9 rs11697325 polymorphism showed a significant association with RAS in the studied population.

Area of Science:

  • Genetics and Oral Medicine
  • Inflammatory Disease Research

Background:

  • Recurrent aphthous stomatitis (RAS) is a prevalent oral inflammatory condition influenced by genetic and environmental factors.
  • Gelatinases (MMP-2, MMP-9) and their inhibitor (TIMP-1) play roles in inflammation.

Purpose of the Study:

  • To investigate the association between specific gene polymorphisms in MMP-2, MMP-9, and TIMP-1 and the susceptibility to RAS.
  • To identify potential genetic markers for RAS risk.

Main Methods:

  • Genotyping of five polymorphisms: rs17576, rs3918242, rs11697325 (MMP-9), rs2285053 (MMP-2), and rs6609533 (TIMP-1).
  • Study included 96 RAS patients and 153 healthy controls.
  • Association analysis using logistic regression and linkage disequilibrium (LD) assessment.

Main Results:

  • A significant association was found between MMP-9 rs11697325 and RAS (OR=3.1, P=0.009).
  • The AA genotype of MMP-9 rs11697325 was more frequent in RAS patients.
  • Strong LD between MMP-9 rs11697325 and rs17576 was observed, with altered haplotype frequencies in patients.

Conclusions:

  • This study provides the first evidence linking MMP-9 gene polymorphisms to RAS susceptibility.
  • The MMP-9 rs11697325 polymorphism is significantly associated with RAS.
  • Further research, including functional studies and replication in diverse populations, is warranted.
Keywords:
matrix metalloproteinasepolymorphismrecurrent aphthous stomatitistissue inhibitors of metalloproteinases

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