Related Experiment Video
Updated: May 7, 2026
A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
Differences in the skin-surface laser Doppler signals between polycystic ovary syndrome and normal subjects
Hsin Hsiu1, Wei-Chen Hsu, Yi-Fan Wu
1Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Background:
Women with PCOS may present abnormal hemodynamic alterations and thus may develop vascular damage. This study performed LDF measurements on the skin surface around the leg to verify if beat-to-beat waveform and spectral analysis can help to discriminate the MBF characteristics between PCOS and healthy subjects.
Methods:
ECG and LDF signals were obtained noninvasively in PCOS (n = 16) and control (n = 8) subjects. Beat-to-beat waveform and spectral analysis was performed on the LDF signals to obtain the AD, FDT, FRT, and REC of five frequency bands.
Results:
FRT was significantly larger, AD was significantly smaller, REC of the myogenic-related band was significantly smaller and REC of the heartbeat-related band was significantly larger in the PCOS than in the control subjects.
Conclusion:
This study is the first to reveal that time-domain waveform and spectral analysis performed on skin-surface LDF signals can be used to discriminate the differences in the MBF perfusion condition and the microcirculatory regulatory activities at local vascular beds between PCOS and healthy subjects. These findings may aid the noninvasive early detection of PCOS-induced vascular damage.
