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Related Concept Videos

Tissues01:18

Tissues

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Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
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Structural Organization of the Human Body: An Overview01:18

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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
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Tissue Engineering of a Human 3D in vitro Tumor Test System
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Human tissue in systems medicine.

Peter D Caie1, Klaas Schuur, Anca Oniscu

  • 1Digital Pathology Unit, Laboratory Medicine, Royal Infirmary of Edinburgh, UK.

The FEBS Journal
|October 15, 2013
PubMed
Summary
This summary is machine-generated.

Systems pathology integrates molecular data with traditional histopathology to enhance diagnosis and prognosis. This approach augments, rather than replaces, current methods for improved patient outcomes.

Keywords:
histopathologyhuman diseasepredictive modelssystems biologysystems medicine

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Area of Science:

  • Pathology
  • Systems Medicine
  • Biomarker Discovery

Background:

  • Traditional histopathology provides static, 2D images for diagnosis and prognosis.
  • Molecular genetic testing and biomarkers show promise for improving diagnostic accuracy and treatment prediction.
  • Current methods face challenges with tissue quality and quantity for predictive modeling.

Purpose of the Study:

  • To argue for a systems medicine approach in pathology that augments traditional methods.
  • To highlight the integration of diverse data types for enhanced predictive models.
  • To address challenges in clinical implementation of systems pathology.

Main Methods:

  • Incorporating quantitative morphological, protein, mRNA, and DNA data.
  • Developing multiscale data sets for comprehensive tissue analysis.
  • Optimizing information extraction from potentially sub-optimal tissue samples.

Main Results:

  • Systems pathology aims to augment, not replace, traditional histopathology.
  • Integration of multiscale data is crucial for robust predictive models.
  • Addressing tissue quality challenges is key for clinical translation.

Conclusions:

  • The transition to systems pathophysiology represents a new era in human tissue analysis.
  • Multiscale data integration enhances diagnosis, prognosis, and treatment prediction.
  • Systems pathology offers a more comprehensive approach to personalized medicine.