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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
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Endoplasmic reticulum stress activates telomerase.

Junzhi Zhou1, Beibei Mao, Qi Zhou

  • 1Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, 310036, China; Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Beijing Normal University, Beijing, 100875, China.

Aging Cell
|October 15, 2013
PubMed
Summary

Endoplasmic reticulum (ER) stress activates telomerase (TERT) expression, impacting cancer cell survival. Increased TERT reduces ER stress-induced cell death, revealing a link between ER stress and telomerase in aging and cancer.

Keywords:
ER stressapoptosishTERTtelomerase

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Telomerase is crucial for cell proliferation and survival.
  • Telomere-dependent and independent mechanisms regulate telomerase.
  • Endoplasmic reticulum (ER) stress is implicated in various pathologies.

Purpose of the Study:

  • To investigate the relationship between ER stress and telomerase.
  • To determine the role of telomerase catalytic component (TERT) in ER stress response.
  • To explore the implications for cancer and aging.

Main Methods:

  • Utilized human cancer cell lines and murine primary neural cells.
  • Assessed TERT expression under ER stress conditions.
  • Depleted and increased hTERT expression to evaluate effects on apoptosis and cell death.

Main Results:

  • ER stress was found to transiently activate TERT expression.
  • Depletion of hTERT sensitized cells to ER stress-induced apoptosis.
  • Increased hTERT expression conferred resistance to ER stress-induced cell death, independent of catalytic activity or DNA damage.

Conclusions:

  • Established a functional link between ER stress and telomerase.
  • TERT plays a significant role in modulating cell fate under ER stress.
  • Findings have implications for understanding aging and cancer pathologies.