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BK and JC virus: a review.
1Division of Infectious and Immunological Diseases, Department of Pediatrics, BC Children's Hospital, Vancouver, Canada.
The Journal of Infection
|October 15, 2013
Summary
BK and JC viruses are common human polyomaviruses. While typically causing mild childhood illness, they can lead to severe diseases like nephropathy and progressive multifocal leukoencephalopathy in immunocompromised individuals.
Area of Science:
- Virology
- Infectious Diseases
- Human Pathogens
Background:
- Polyomaviruses are ubiquitous, species-specific viruses.
- BK and JC viruses are the most well-known human polyomaviruses, identified in the 1970s.
- Newer polyomaviruses, including KI, WU, and Merkel cell polyomaviruses, have been identified recently.
Purpose of the Study:
- To outline the virology, epidemiology, and clinical manifestations of BK and JC viruses.
- To discuss diagnostic and treatment options for BK and JC virus infections.
Main Methods:
- Literature review of polyomavirus research.
- Analysis of clinical case studies and epidemiological data.
Main Results:
- Most individuals are exposed to BK and JC viruses in childhood with mild symptoms.
- Reactivation or acquisition in immunocompromised hosts can lead to significant clinical disease.
- BK virus is primarily associated with renal diseases, while JC virus is linked to progressive multifocal leukoencephalopathy and potential neoplasms.
Conclusions:
- BK and JC viruses represent significant human pathogens, particularly in immunocompromised populations.
- Understanding their pathogenesis is crucial for effective diagnosis and management.
- Further research into novel polyomaviruses and their clinical impact is warranted.
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