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The acute antihypertensive effect of ketanserin increases with age
Abstract:
The relationship between the acute blood pressure lowering effect of ketanserin with age was investigated in 57 patients ranging from 25 to 90 years (mean 61 years). There was a highly significant correlation between the degree of reduction of systolic and diastolic blood pressure and age, independent of the starting blood pressure. The fact that the acute blood pressure-lowering effect of ketanserin increases with age may suggest a role for serotonin in blood pressure regulation, particularly in elderly patients.
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