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Peptic ulcer disease and mental illnesses
Wei-Yen Lim1, Mythily Subramaniam2, Edimansyah Abdin2
1Saw Swee Hock School of Public Health, National University of Singapore & National University Health System, Singapore; Research Division, Institute of Mental Health, Singapore.
General Hospital Psychiatry
|October 15, 2013
Summary
Peptic ulcer disease (PUD) is linked to anxiety disorders, with this connection remaining strong even after accounting for nicotine and alcohol use. This association also impacts quality of life.
Area of Science:
- Gastroenterology
- Psychiatry
- Epidemiology
Background:
- Peptic ulcer disease (PUD) is a common gastrointestinal condition.
- Mental disorders are prevalent and impact overall health.
- The relationship between PUD and mental health requires further investigation.
Purpose of the Study:
- To investigate the association between doctor-diagnosed peptic ulcer disease (PUD) and various mental disorders.
- To explore the influence of anxiety disorders, mood disorders, and substance use on PUD prevalence.
- To assess the impact of PUD and co-occurring mental disorders on quality of life.
Main Methods:
- A cross-sectional study in Singapore involving 6616 community-dwelling individuals.
- Doctor-diagnosed PUD history was self-reported.
- Mental disorders were assessed using the World Mental Health Composite International Diagnostic Interview version 3.0.
- Quality of life was measured using the EuroQoL 5D.
Main Results:
- The prevalence of PUD was 1.58%.
- PUD was significantly associated with anxiety disorders (including obsessive-compulsive disorder and generalized anxiety disorder) and mood disorders.
- The association between PUD and anxiety disorders persisted after adjusting for nicotine and alcohol use.
- PUD was linked to reduced quality of life, further diminished by the presence of mental disorders.
Conclusions:
- Anxiety disorders are significantly associated with peptic ulcer disease (PUD).
- This association remains robust even after controlling for nicotine dependence and alcohol use disorder.
- PUD and co-existing mental health conditions negatively affect quality of life.
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