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Mechanisms of MAVS regulation at the mitochondrial membrane

Jana L Jacobs1, Carolyn B Coyne

  • 1Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Journal of Molecular Biology
|October 15, 2013
PubMed

Insights

Mitochondria are key to antiviral immunity, housing the MAVS protein that activates immune genes. This review explores how cells regulate MAVS to control inflammation and prevent damage.

Area of Science:

  • Mitochondrial biology
  • Innate immunity
  • Virology

Background:

  • Mitochondria are central to innate immune signaling against viruses.
  • The mitochondrial antiviral signaling protein (MAVS) is a key adaptor coordinating signals from pathogen recognition receptors (PRRs).
  • MAVS regulates the induction of antiviral genes.

Purpose of the Study:

  • To review the MAVS regulome.
  • To explore cellular factors that regulate MAVS.
  • To understand how MAVS controls inflammation and prevents cellular damage.

Main Methods:

  • Literature review focusing on MAVS regulation.
  • Analysis of protein-protein interactions affecting MAVS.
  • Examination of mitochondrial dynamics' role in MAVS signaling.
  • Review of post-translational modifications impacting MAVS.

Main Results:

  • MAVS integrates signals from cytosolic PRRs on the mitochondria.
  • Regulation of MAVS expression and signaling is crucial for controlling inflammation.
  • Cellular factors modulate MAVS through protein interactions, mitochondrial dynamics, and PTMs.

Conclusions:

  • MAVS is a critical regulator of the antiviral innate immune response.
  • Understanding MAVS regulation is key to controlling inflammatory diseases.
  • Targeting MAVS pathways offers therapeutic potential for viral infections.
Keywords:
CARDCOX5BERFAKIRF3MAMMAVSMDA5PCBP2PLK1Polo-like kinase 1RIG-IRIG-I-like receptorRLRROSSeVSendai virusTANK binding kinase 1TBK1VSVcaspase activation and recruitment domaincytochrome C oxidase 5Bendoplasmic reticulumfocal adhesion kinaseinnate immunityinterferon regulatory factor 3melanoma differentiation-associated gene 5mitochondria-associated membranepoly(rC) binding protein 2reactive oxygen speciesretinoic acid-inducible gene-IvRNAvesicular stomatitis virusviral RNA

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