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Substance P antagonists and mucociliary activity in rabbit
Naunyn-Schmiedeberg'S Archives of Pharmacology
|June 1, 1985
Summary
Substance P (SP) accelerates mucociliary activity. A novel antagonist, [D-Pro2,D-Trp7,9]SP, confirmed SP
Area of Science:
- Respiratory Physiology
- Neuropharmacology
- Airway Biology
Background:
- Substance P (SP) is known to enhance mucociliary (m.c.) activity in rabbit maxillary sinus.
- The physiological role of SP in airway clearance is not fully understood.
Purpose of the Study:
- To investigate the physiological significance of SP-mediated mucociliary activity.
- To identify effective SP antagonists for studying SP's role in airway physiology.
Main Methods:
- In vivo testing of three putative SP antagonists in rabbit maxillary sinus model.
- Assessment of antagonist effects on SP-induced and other stimulant-induced mucociliary activity.
- Pharmacological characterization of [D-Pro2,D-Trp7,9]SP as an SP antagonist.
Main Results:
- [D-Pro2,D-Trp7,9]SP demonstrated reversible antagonism of SP-induced mucociliary activity.
- This antagonist also inhibited bradykinin- and capsaicin-induced activity, suggesting SP release.
- Methacholine-induced activity was not inhibited, indicating pathway specificity.
Conclusions:
- Bradykinin and capsaicin may stimulate mucociliary activity partly via SP release.
- SP's acceleration of mucociliary activity likely involves physiological protective mechanisms.
- [D-Pro2,D-Trp7,9]SP is a valuable tool for researching SP's role in rabbit airway function.