Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surface substance loss of subsurface bovine enamel lesions after different steps of the resinous infiltration technique: a 3D topography analysis.

Odontology·2011

Same author

Expression of IL-23/Th17 pathway in a murine model of Coxsackie virus B3-induced viral myocarditis.

Virology journal·2011

Same author

Extracellular matrix peptides of Artemia cyst shell participate in protecting encysted embryos from extreme environments.

PloS one·2011

Same author

Therapeutic effect of carboxymethylated and quanternized chitosan on insulin resistance in high-fat-diet-induced rats and 3T3-L1 adipocytes.

Journal of biomaterials science. Polymer edition·2011

Same author

Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2011

Same author

Chlorination and ortho-acetoxylation of 2-arylbenzoxazoles.

Organic & biomolecular chemistry·2011

Same journal

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial).

Journal of visualized experiments : JoVE·2026

Same journal

A Standardized Ex Vivo Porcine Oromucosal Model for Evaluating Peptide Fluxes.

Journal of visualized experiments : JoVE·2026

Same journal

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026

Same journal

Integrating Artificial Intelligence-Assisted Translation Support into English Courses: Effects on Translation Accuracy, Perceived Stress, and Anxiety.

Journal of visualized experiments : JoVE·2026

Same journal

A Toxin-Based Counter-Selection System for Markerless Gene Deletion and High-Density Tn5 Transposon Mutagenesis in Pectobacterium brasiliense.

Journal of visualized experiments : JoVE·2026

Same journal

Seamless Multimodal Human-Robot Communication: Integration Techniques in Human-Computer Interaction.

Journal of visualized experiments : JoVE·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 7, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

Programming stem cells for therapeutic angiogenesis using biodegradable polymeric nanoparticles.

Michael Keeney¹, Lorenzo Deveza, Fan Yang

¹Department of Orthopaedic Surgery, Stanford University.

Journal of Visualized Experiments : Jove

|October 15, 2013

Summary

This summary is machine-generated.

This study developed a novel method using biodegradable nanoparticles to program stem cells for enhanced vascular growth. These engineered stem cells effectively promote blood vessel formation in ischemic tissues, offering a promising therapeutic strategy.

More Related Videos

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Area of Science:

Biomedical Engineering
Regenerative Medicine
Vascular Biology

Background:

Controlled vascular growth is essential for tissue regeneration and treating ischemic diseases.
Direct delivery of angiogenic factors faces challenges like poor targeting and short in vivo half-life.
Gene therapy for angiogenesis often involves viral vectors with safety concerns.

Purpose of the Study:

To develop a novel strategy for stimulating vascular growth using stem cells programmed to overexpress angiogenic factors.
To utilize biodegradable polymeric nanoparticles for in situ gene delivery into stem cells.
To evaluate the efficacy of engineered stem cells in promoting angiogenesis in a preclinical model.

Main Methods:

Synthesis of biodegradable polymeric nanoparticles for gene delivery.
Programming adipose-derived stem cells to overexpress vascular endothelial growth factor (VEGF) using nanoparticles.
In vitro characterization of transfected stem cells.
In vivo assessment of VEGF-expressing stem cells in a murine hindlimb ischemia model.

Main Results:

Successful modification of adipose-derived stem cells to overexpress VEGF via nanoparticle-mediated gene delivery.
Demonstrated stem cell migration towards ischemic tissues.
Validation of enhanced angiogenesis and improved vascularization in the hindlimb ischemia model.

Conclusions:

Stem cell-based delivery of angiogenic factors using biodegradable nanoparticles is a viable strategy for promoting vascular growth.
This approach overcomes limitations of direct factor delivery and viral gene therapy.
Engineered stem cells hold significant potential for treating ischemic diseases and enhancing tissue regeneration.