Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 7, 2026

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
11:49

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

16.5K

Vanishing corneal vessels.

Luke Nicholson1, Rupinder Chana

  • 1Department of Ophthalmology, Royal Gwent Hospital, Cardiff, UK.

BMJ Case Reports
|October 15, 2013
PubMed
Summary
This summary is machine-generated.

Topical phenylephrine eye drops can mask superficial corneal vascularization, a condition important for corneal graft patients to monitor. Prompt recognition of this side effect is crucial for accurate eye assessments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world early outcomes of intravitreal faricimab 6-mg and aflibercept 2-mg injection in diabetic macular oedema.

The British journal of ophthalmology·2026
Same author

Beyond Cost: Faricimab as a Driver of Service Efficiency and Quality in Neovascular Age-Related Macular Degeneration Care.

Ophthalmology and therapy·2026
Same author

Clinical spectrum of intraocular inflammation following faricimab intravitreal injections: evidence from a large real-life cohort in the United Kingdom.

Eye (London, England)·2026
Same author

Update on subthreshold micropulse laser treatment for retinal diseases: A narrative review.

Survey of ophthalmology·2026
Same author

Cartilage Defect Articulation With the Proximal Phalanx After Retrograde Intramedullary Screw Fixation of Metacarpal Fractures: A Cadaveric Study.

Journal of hand surgery global online·2025
Same author

Characteristics and outcomes of cubital tunnel decompression in diabetic patients receiving glucagon-like peptide-1 receptor agonists.

Clinics in shoulder and elbow·2025
Same journal

Central serous chorioretinopathy associated with topical prostaglandin analogues.

BMJ case reports·2026
Same journal

Aberrant macular artery with absent foveal pit and retained inner retinal layers.

BMJ case reports·2026
Same journal

Post-traumatic cervical dystonia treated with botulinum toxin type A injections to the cranial and cervical muscles.

BMJ case reports·2026
Same journal

Light chain-mediated acute tubulointerstitial nephritis as the sole manifestation of monoclonal gammopathy of renal significance in a young adult.

BMJ case reports·2026
Same journal

Late diagnosis of late onset Fabry disease.

BMJ case reports·2026
Same journal

Pelvic desmoid fibromatosis: a diagnostic and therapeutic challenge.

BMJ case reports·2026
See all related articles

Area of Science:

  • Ophthalmology
  • Corneal disease
  • Ophthalmic pharmacology

Background:

  • Topical phenylephrine is commonly used for mydriasis (pupil dilation).
  • Superficial corneal vascularization can indicate underlying ocular issues.
  • Corneal graft recipients require vigilant monitoring for complications.

Observation:

  • A 92-year-old female corneal graft recipient presented with previously undocumented superficial corneal vascularization.
  • Instillation of phenylephrine and tropicamide temporarily obscured the corneal vascularization.
  • Subsequent assessment revealed phenylephrine as the sole agent responsible for masking the vascularization.

Findings:

  • Phenylephrine, not tropicamide, caused the masking of superficial corneal vascularization.

More Related Videos

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.2K
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
10:52

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

17.7K

Related Experiment Videos

Last Updated: May 7, 2026

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
11:49

The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye

Published on: August 16, 2014

16.5K
Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

2.2K
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
10:52

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

17.7K
  • This effect can lead to underdiagnosis of corneal complications.
  • The vascularization became visible again after the effects of phenylephrine subsided.

    • Implications:

    • Phenylephrine instillation prior to examination may mask significant corneal findings.
    • Ophthalmologists, particularly in cornea clinics, should be aware of this masking effect.
    • Careful patient history and examination are essential to avoid misdiagnosis in patients using phenylephrine.