Surgical management of non-colorectal hepatic metastasis

Isolated hepatic metastases from non-colorectal primary tumors are rare. Patients with neuroendocrine tumors have an indolent biology compared with other non-colorectal histologies. This article discusses the surgical management options for patients with neuroendocrine liver metastases and, separately, for those with non-colorectal, non-neuroendocrine metastases. Emphasis is placed on the importance of patient selection, understanding the tumor biology and response to systemic therapy.