Coronary artery revascularization before peripheral vascular surgery in patients with peripheral arterial disease
Hideki Miyachi1, Jun Tanabe, Eitaro Kodani
1Division of Cardiology, National Hospital Organization Shizuoka Medical Center, Shizuoka, Japan, hidep-@nms.ac.jp.
Insights
Coronary artery revascularization before peripheral vascular surgery did not improve long-term outcomes for patients with coronary artery disease and inducible ischemia. Pre-operative evaluation is key for treatment strategy.
Area of Science:
- Cardiology
- Vascular Surgery
- Cardiovascular Research
Background:
- Peripheral arterial disease (PAD) frequently coexists with coronary artery disease (CAD), increasing perioperative cardiac risks during peripheral vascular surgery (PVS).
- The benefit of routine coronary artery revascularization before PVS in patients with PAD and CAD is not well-established.
Purpose of the Study:
- To evaluate the long-term efficacy of coronary artery revascularization in patients with PAD undergoing elective PVS.
- To compare outcomes between patients with CAD who underwent revascularization, those treated medically, and those without CAD.
Main Methods:
- Retrospective analysis of 114 patients undergoing elective PVS.
- Coronary angiography (CAG) performed preoperatively.
- Groups: No-CAD (n=62), CAD-Medical (n=37), CAD-Revascularization (n=15) based on CAG findings and ischemia assessment.
Main Results:
- Postoperative 30-day event rates were 8.1% (No-CAD), 10.8% (CAD-M), and 26.7% (CAD-R) (P=0.13).
- Long-term cardiovascular event rates were 21.0% (No-CAD), 21.6% (CAD-M), and 33.3% (CAD-R) (P=0.60).
- Outcomes were comparable across groups, suggesting no significant benefit from revascularization in this cohort.
Conclusions:
- Coronary artery revascularization prior to elective PVS did not yield superior long-term outcomes compared to medical management or no CAD.
- Comprehensive evaluation of CAD and myocardial ischemia is crucial for determining optimal therapeutic strategies before PVS.
- Individualized treatment decisions for CAD in PAD patients undergoing PVS are warranted.
Abstract:
The prevalence of coronary artery disease (CAD) in patients with peripheral arterial disease (PAD) approaches 50%. The incidence of perioperative cardiac complications is high in patients undergoing peripheral vascular surgery (PVS). However, the long-term efficacy of coronary artery revascularization in patients with PAD prior to PVS remains controversial. We retrospectively analyzed the long-term outcomes of 114 patients who underwent elective PVS. Coronary angiography (CAG) was performed routinely in all patients prior to the surgery. Preoperative CAG revealed CAD in 52 patients and no CAD in 62 patients (No-CAD group). Of the 52 patients with CAD, 15 patients with effort angina (more than CCS class 2), myocardial ischemia proven by pharmacological stress scintigraphy, and/or multivessel disease with impaired left ventricular systolic function underwent coronary revascularization (CAD-R group). The remaining 37 patients with CAD were treated medically (CAD-M group). The rates of postoperative events within 30 days were 26.7% in the CAD-R group, 10.8% in the CAD-M group, and 8.1% in the No-CAD group, respectively (P = 0.13), and the rates of long-term cardiovascular events were 33.3, 21.6, and 21.0%, respectively (P = 0.60). Therefore, the acute and long-term clinical outcomes in the CAD-R group were comparable with the other groups. In this study, the patients with CAD who showed inducible myocardial ischemia and/or multivessel disease with impaired left ventricular systolic function underwent coronary artery revascularization prior to the elective PVS. The patients who underwent coronary revascularization prior to the PVS exhibited comparable long-term outcomes compared with the patients who showed CAD but without inducible myocardial ischemia and with those without CAD. These data suggest that the evaluation of CAD and myocardial ischemia to determine the therapeutic strategy for CAD before elective PVS would be needed.
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