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Long-term safety and efficacy of low-dose clopidogrel in Japanese patients undergoing coronary stenting: a
Kenji Ohkubo1, Yoshio Kobayashi
1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba, 260-8677, Japan.
Abstract:
This study evaluated long-term safety and efficacy of low-dose (50-mg) clopidogrel in Japanese patients undergoing coronary stenting. A total of 126 patients with 153 lesions who consented to take a 50-mg maintenance dose of clopidogrel to prevent stent thrombosis were enrolled. The duration of clinical follow-up was 13.9 ± 9.7 months. There was one early stent thrombosis (0.65%). Neither late nor very late stent thrombosis was observed in patients on clopidogrel plus aspirin. Side effects of clopidogrel were observed in 9 patients (7.1%). This preliminary study shows that 50-mg maintenance dose of clopidogrel may be acceptable in Japanese patients undergoing coronary stenting.
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