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Updated: May 7, 2026

Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
Published on: July 16, 2011
TLRs control hematopoiesis during infection
Alberto Yáñez1, Helen S Goodridge, Daniel Gozalbo
1Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Research Division of Immunology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Abstract:
Recent research has shown that (i) Toll-like receptor (TLR) agonists drive hematopoietic stem and progenitor cells (HSPCs) to proliferate and differentiate along the myeloid lineage in vitro, and (ii) direct TLR-mediated stimulation of HSPCs also promotes macrophage differentiation in vivo following infection. These new insights demonstrate that TLR signaling in HSPCs, in addition to other TLR-dependent mechanisms, can contribute to HSPC expansion and myeloid differentiation after infection. Evidence is, therefore, mounting that direct TLR-induced programming of hematopoiesis plays a key role in host defense by rapidly replenishing the innate immune system with the cells needed to deal with pathogens.
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