Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

223
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
223
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

4.3K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
4.3K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

9.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.1K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.6K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.6K
Hypersensitivities01:30

Hypersensitivities

7.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a high-grade glioma preclinical surgery model using an inducible KRAS/TP53 Oncopig.

Frontiers in oncology·2026
Same author

Evaluation of a near-infrared version of TMR-PEG1k, a high-performance untargeted contrast agent for fluorescence-guided surgery, using fluorescence cryotomography.

Journal of biomedical optics·2025
Same author

Fully automated image updating for brain shift compensation after dural opening.

Journal of neurosurgery·2025
Same author

Prediction of seizure outcome with presurgical intracarotid amobarbital procedure, mesial temporal sclerosis on MRI, and PET in surgical candidates with temporal lobe epilepsy.

Epileptic disorders : international epilepsy journal with videotape·2025
Same author

Probing "hydridic hydrogen bonds" using energy decomposition analysis based on absolutely localized molecular orbitals.

Physical chemistry chemical physics : PCCP·2025
Same author

Erratum: Elucidating the effect of tumor and background region-of-interest selection on the performance metrics used to assess fluorescence imaging (Erratum).

Journal of biomedical optics·2025

Related Experiment Video

Updated: May 7, 2026

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model
21:16

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model

Published on: July 13, 2009

70.3K

Integrated testing and assessment approaches for skin sensitization: a commentary.

David W Roberts1, Grace Y Patlewicz

  • 1Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool, L3 3AF, UK.

Journal of Applied Toxicology : JAT
|October 15, 2013
PubMed
Summary

A Bayesian integrated testing strategy (ITS) effectively predicts skin sensitization potency by combining in vitro data. This approach aligns with chemistry-based modeling, highlighting reactivity

Keywords:
BayesianChemical reactivityHyodrophobicityKineticsMechanism-base modeling

More Related Videos

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

13.9K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K

Related Experiment Videos

Last Updated: May 7, 2026

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model
21:16

An In Vitro Skin Irritation Test SIT using the EpiDerm Reconstructed Human Epidermal RHE Model

Published on: July 13, 2009

70.3K
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

13.9K
Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K

Area of Science:

  • Toxicology
  • Computational Chemistry
  • Dermatology

Background:

  • Assessing skin sensitization potency is crucial for chemical safety.
  • Existing methods include in vitro assays and computational modeling.
  • Integrating diverse data sources can improve predictive accuracy.

Purpose of the Study:

  • To compare a Bayesian integrated testing strategy (ITS) with a quantitative mechanistic modeling (QMM) approach for predicting skin sensitization potency.
  • To evaluate the strengths and limitations of each approach in assessing chemical reactivity and bioavailability.

Main Methods:

  • Bayesian integrated testing strategy (ITS) utilizing in vitro assay data.
  • Quantitative mechanistic modeling (QMM) based on physical organic chemistry principles.
  • Comparison of predictive performance for skin sensitization potency categories and numerical values.

Main Results:

  • Bayesian ITS findings are consistent with QMM, emphasizing the high predictive value of chemical reactivity data.
  • Bioavailability parameters showed relatively low predictive value in both approaches.
  • The current Bayesian ITS assigns potency categories, while QMM can provide numerical predictions for many chemicals.

Conclusions:

  • Both Bayesian ITS and QMM approaches highlight the importance of chemical reactivity in predicting skin sensitization.
  • QMM offers numerical potency predictions, whereas Bayesian ITS currently provides categories.
  • Bayesian ITS may complement QMM for complex cases like pro-electrophiles, underscoring the value of integrated chemistry insights and read-across.