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Opioid poisonings and opioid adverse effects in workers in Washington state
Deborah Fulton-Kehoe1, Renu K Garg, Judith A Turner
1Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington.
Objective:
To examine trends in opioid poisonings and adverse effects in Washington (WA) State and nationally.
Methods:
We calculated rates of opioid poisonings and adverse effects and examined opioid prescriptions in the WA workers' compensation system, 2004-2010. Using Health Care Cost and Utilization Project (HCUP), Nationwide Inpatient Sample (NIS) data, we also calculated national rates of opioid poisonings and adverse effects, 1993-2010.
Results:
We identified 96 opioid poisonings and 312 opioid-related adverse effects in WA, 2004-2010. The rates did not change substantially over these years. Most poisonings and adverse effects occurred in cases without chronic opioid use and with prescribed doses <120 mg/day morphine-equivalent dose. Nationally, the rates of opioid poisonings and adverse effects increased significantly from 1993 to 2010.
Conclusions:
Many poisonings and adverse effects occurred in patients without high dose or long-term opioid therapy, suggesting that opioid dosing and duration guidelines may not be sufficient to reduce morbidity related to prescription opioid use.
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