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Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone

Mitsuo Ofude1, Atsushi Mizokami, Misako Kumaki

  • 1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8640, Japan. mizokami@med.kanazawa-u.ac.jp.

Anticancer Research
|October 15, 2013
PubMed
Abstract

Insights

2'-hydroxyflavanone inhibits prostate cancer cell growth and androgen signaling. This compound may help prevent castration-resistant prostate cancer recurrence by reducing proliferation and androgen receptor activity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Hormone-naïve prostate cancer progression to castration-resistant prostate cancer impacts patient quality of life.
  • Identifying agents to prevent this progression is a critical clinical challenge.

Purpose of the Study:

  • To investigate the effects of 2 -hydroxyflavanone on prostate cancer cell proliferation.
  • To determine the impact of 2 -hydroxyflavanone on androgen responsiveness in prostate cancer cells.

Main Methods:

  • Prostate cancer cell lines (PC-3, DU145, LNCaP) were treated with 2 -hydroxyflavanone.
  • Androgen responsiveness was assessed using a luciferase assay with the prostate-specific antigen promoter.
  • Androgen receptor (AR) expression was analyzed via reverse transcriptase polymerase chain reaction and western blot.

Main Results:

  • 2 -Hydroxyflavanone induced apoptosis and inhibited proliferation in PC-3 and DU145 cells.
  • 2 -Hydroxyflavanone suppressed androgen-stimulated proliferation in LNCaP cells.
  • Treatment with 2 -hydroxyflavanone led to down-regulation of AR protein, attenuating androgen responsiveness.

Conclusions:

  • 2 -Hydroxyflavanone demonstrates anti-proliferative effects on prostate cancer cells.
  • The compound effectively represses androgen responsiveness by reducing AR protein levels.
  • 2 -Hydroxyflavanone shows potential as a therapeutic agent to prevent prostate cancer recurrence.
Keywords:
2’-hydroxyflavanoneProstate cancerandrogenandrogen receptor

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