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Parent education and biologic factors influence on cognition in sickle cell anemia

Allison A King1, John J Strouse, Mark J Rodeghier

  • 1Program in Occupational Therapy and Department of Pediatrics Hematology/Oncology, Washington University School of Medicine, St. Louis, Missouri.

American Journal of Hematology
|October 15, 2013
PubMed

Insights

Silent cerebral infarcts (SCIs) and lower parental education significantly impact full-scale intelligence quotient (FSIQ) in children with sickle cell anemia. Socioeconomic and biological factors are crucial for cognitive development in these children.

Area of Science:

  • Pediatrics
  • Neurology
  • Genetics

Background:

  • Sickle cell anemia (SCA) is linked to silent cerebral infarcts (SCIs), which negatively affect cognitive function.
  • Parental education is a known predictor of child cognitive development, but its role in SCA is unclear.

Purpose of the Study:

  • To investigate the impact of SCIs and parental education on full-scale intelligence quotient (FSIQ) in children with SCA.

Main Methods:

  • A multicenter, cross-sectional study involved 150 children (ages 5-15) with SCA.
  • Participants were screened for SCIs and underwent cognitive assessment using the Wechsler Abbreviated Scale of Intelligence.

Main Results:

  • Lower parental education, presence of SCIs, lower family income, older age, and decreased hemoglobin oxygen saturation were associated with lower FSIQ.
  • Specifically, absence of college education correlated with a 6.2-point FSIQ decrease, and SCIs with a 5.2-point decrease.

Conclusions:

  • FSIQ in children with SCA is influenced by a combination of biological and socioeconomic factors.
  • Multivariate models incorporating these factors provide a comprehensive understanding of cognitive outcomes in SCA.

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