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Updated: May 7, 2026
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
The effects of strength, aerobic, and concurrent exercise on skeletal muscle damage in rats
Anderson Rech1, Regis Radaelli, Adriano M De Assis
1Exercise Research Laboratory, School of Physical Education, Federal University of Rio Grande do Sul, St. Felizardo, 750, LAPEX Building, Porto Alegre, RS, 90690-200, Brazil.
Introduction:
In this study we examined oxidative stress and skeletal muscle damage resulting from acute strength, aerobic, or concurrent exercise in rats.
Methods:
The animals were divided into control (C), strength (SE), aerobic (AE), and combined (CE) exercise groups. They were euthanized at 3 different time-points (6, 24, and 48 h) after acute exercise.
Results:
SE exercise rats had increased dichlorofluorescein oxidation at 6 h post-exercise and decreased superoxide dismutase activity at all time-points. Glutathione peroxidase activity and sulfhydryl levels were increased in the AE group at 48 h post-exercise. Serum lactate dehydrogenase activity was increased in the SE and CE groups at 24 h and in the AE group at 48 h. Echo intensity was elevated at 24 h for all groups.
Conclusions:
Forty-eight hours was sufficient for complete recovery from oxidative stress and muscle damage in the SE and CE groups, but not in the AE group.
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