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Updated: May 7, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Heterogeneous Cu(II) -catalysed solvent-controlled selective N-arylation of cyclic amides and amines with
Debasish Kundu1, Sukalyan Bhadra, Nirmalya Mukherjee
1Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032 (India), Fax: (+91) 33-24732805.
Abstract:
A selective N-arylation of cyclic amides and amines in DMF and water, respectively, catalysed by Cu(II) /Al2 O3 has been achieved. This protocol has been employed for the synthesis of a library of arenes bearing a cyclic amide and an amine moiety at two ends, including a few scaffolds of therapeutic importance. The mechanism has been established based on detailed electron paramagnetic resonance (EPR) spectroscopy, X-ray photoelectron spectroscopy (XPS), UV diffuse reflectance spectroscopy (DRS) and inductively coupled plasma-mass spectrometry (ICP-MS) studies of the catalyst at different stages of the reaction. The Cu(II) /Al2 O3 catalyst was recovered and recycled for subsequent reactions.
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