Enantioselective liquid-liquid extraction of zopiclone with mandelic acid ester derivatives
Yangfeng Peng1, Quan He, Bin Zuo
1Department of Chemical Engineering, East China University of Science and Technology, Shanghai, China.
Abstract:
Enantioselective liquid-liquid extraction of zopiclone was conducted by employing a series of (R)-mandelic acid esters as chiral extractants. The effects of concentration of extractant, concentration of zopiclone, type of organic solvent, pH value, and temperature on the extraction efficiency were investigated. (R)-o-chloromandelic acid propyl ester was demonstrated to be an efficient chiral extractant for zopiclone resolution with a maximum enantioselectivity of 1.6.
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