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T2*-correction in dynamic contrast-enhanced MRI from double-echo acquisitions.

Magne Kleppestø1, Christopher Larsson, Inge Groote

  • 1The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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T2*-effects in dynamic contrast-enhanced MRI of high-grade gliomas significantly overestimate kinetic parameters like blood plasma volume (vp) if not corrected. Accurate quantification requires accounting for these T2*-effects in the arterial input function (AIF).

Keywords:
AIFDCE-MRIT2* correctionT2*-effectdynamic contrast-enhanced MRIglioma

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Area of Science:

  • Radiology
  • Medical Imaging
  • Oncology

Background:

  • Dynamic contrast-enhanced (DCE) MRI is crucial for assessing high-grade gliomas.
  • Accurate kinetic parameter estimation is vital for treatment planning and monitoring.
  • T2*-effects can introduce significant artifacts in MRI signal quantification.

Purpose of the Study:

  • To evaluate the impact of T2*-effects on the arterial input function (AIF).
  • To assess the influence of T2*-effects on kinetic parameter estimation in high-grade glioma DCE-MRI.
  • To determine the necessity of T2*-correction for accurate DCE-MRI quantification.

Main Methods:

  • Seven high-grade glioma patients underwent 50 DCE-MRI scans using a double-echo sequence.
  • Kinetic analysis with the extended Tofts model was performed with and without AIF T2*-correction.
  • Parameters including K(trans), vp, and kep were compared; numerical simulations were also conducted.

Main Results:

  • All kinetic parameters were overestimated without T2*-correction, with vp being most affected.
  • Parameter overestimation was dependent on the absolute parameter magnitude.
  • Uncorrected AIF T2*-effects led to inaccurate parametric tumor distribution maps.

Conclusions:

  • T2*-effects significantly impact DCE-MRI quantification in high-grade gliomas.
  • Correction for T2*-effects in the AIF is essential for accurate kinetic parameter estimation.
  • Utilizing short echo times or double-echo acquisition with correction is recommended for reliable DCE-MRI analysis.