Palladium-catalyzed cross-dehydrogenative functionalization of C(sp(2))-H Bonds
1State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (Hong Kong), Fax: (+852) 2364-9932; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou (China).
Palladium-catalyzed reactions enable carbon-carbon bond formation via cross-dehydrogenative coupling (CDC) of C-H bonds. This review highlights advances in palladium-catalyzed CDC reactions involving C(sp2)-H bonds from 2011 to early 2013.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Catalytic cross-dehydrogenative coupling (CDC) reactions are gaining prominence in organic synthesis.
- CDC reactions facilitate C-C bond formation by coupling two C-H bonds under oxidative conditions.
- Palladium catalysis is a key area of research for developing efficient CDC methodologies.
Purpose of the Study:
- To summarize recent advancements in palladium-catalyzed CDC reactions.
- To focus specifically on reactions involving the C(sp2)-H bond.
- To cover the scientific literature from 2011 to early 2013.
Main Methods:
- Review of recent literature on palladium-catalyzed CDC reactions.
- Focus on C(sp2)-H bond activation and coupling.
- Analysis of oxidative coupling strategies.
Main Results:
- Significant progress has been made in palladium-catalyzed CDC reactions of C(sp2)-H bonds.
- Various catalytic systems and reaction conditions have been developed.
- The scope and efficiency of these coupling reactions have been expanded.
Conclusions:
- Palladium-catalyzed CDC reactions represent a powerful tool for C-C bond formation.
- Continued research is expanding the utility of CDC in organic synthesis.
- The period from 2011-2013 saw notable developments in this field.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
Related Concept Videos
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Cycloaddition Reactions: Overview
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)