Cloning and sequencing of the chaetocin biosynthetic gene cluster
Thomas Gerken1, Christopher T Walsh
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115 (USA); Current address: Metanomics GmbH, Tegeler Weg 33, 10589 Berlin (Germany).
Chembiochem : a European Journal of Chemical Biology
|October 15, 2013
Abstract:
How a fungus does it: The epidithiodiketopiperazine (ETP) fungal alkaloids, which include gliotoxin, have garnered much attention since their initial isolation. The cloning and sequencing of the biosynthetic gene cluster for another ETP, chaetocin A were used to suggest a route towards dimerization and sulfur incorporation in these molecules.
