Related Experiment Video
Updated: May 7, 2026
07:19
Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
Published on: August 4, 2021
6.5K
Photoactivation of a psoralen-blocked luciferase gene by blue light
Thorsten Stafforst1, Jens M Stadler
1Interfaculty Institute of Biochemistry, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen (Germany) http://www.ifib.uni-tuebingen.de/forschung/stafforst.html. thorsten.stafforst@uni-tuebingen.de.
Angewandte Chemie (International Ed. in English)
|October 15, 2013
Abstract:
A single psoralen cross-link completely blocks expression of a gene. An aminopyrene derivative has been found that allows the efficient light-triggered activation of cross-linked genes by UV or blue light. This paves the way to apply such psoralen cross-links for the photocleavable protection of nucleic acids.
