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Updated: May 7, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Outcomes and prognostic factors in superficial spreading melanoma
Michael E Egger1, Lindsay O Stepp, Glenda G Callender
1Hiram C. Polk Jr MD Department of Surgery, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA.
Background:
Prognostic factors and risk factors for positive sentinel lymph node (SLN) biopsy results are important to identify in superficial spreading melanoma (SSM).
Methods:
A single-center database and a prospective clinical trial database were reviewed for all patients with diagnoses of SSM. Logistic regression, Kaplan-Meier survival analysis, and univariate and multivariate Cox models were used.
Results:
A total of 1,643 patients with SSM were identified. Independent risk factors for positive SLN biopsy results were Breslow thickness (BT) ≥2.0 mm, age <60 years, and presence of ulceration. BT ≥2.0 mm, ulceration, lymphovascular invasion, and positive SLN and positive non-SLN biopsy results were independent risk factors for worse disease-free survival. Independent overall survival risk factors included BT ≥2.0 mm, age ≥60 years, ulceration, nonextremity tumor location, lymphovascular invasion, and positive SLN biopsy results.
Conclusions:
BT, ulceration, lymphovascular invasion, and SLN and non-SLN status are important risk factors for SSM.
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