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[Impact of diabetes on clinical outcomes following multivessel percutaneous interventions]

Yan Qiao1, Shao-ping Nie, Xin Du

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.

Zhonghua Yi Xue Za Zhi
|October 16, 2013
PubMed

Insights

Diabetes significantly increases risks of mortality and stent thrombosis in patients with multivessel disease undergoing percutaneous coronary intervention (PCI). These findings highlight the critical impact of diabetes on long-term cardiovascular outcomes after PCI.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Diabetology

Context:

  • Multivessel disease poses significant risks for cardiovascular events.
  • Percutaneous coronary intervention (PCI) with stent implantation is a common treatment for multivessel disease.
  • The impact of diabetes on long-term outcomes after PCI in this population requires further elucidation.

Purpose:

  • To compare mortality, myocardial infarction (MI), repeat revascularization, and stent thrombosis rates between diabetic and nondiabetic patients with multivessel disease after PCI.
  • To evaluate the long-term clinical outcome differences attributed to diabetes in patients undergoing PCI for multivessel disease.

Summary:

  • A study of 1985 patients with multivessel disease found that after 24 months, diabetics had significantly higher adjusted risks of all-cause mortality (4.4% vs 2.0%) and cardiac mortality (2.7% vs 1.1%) compared to nondiabetics.
  • While nonfatal MI and repeat revascularization rates were similar, diabetes was associated with a significantly increased risk of stent thrombosis.
  • The overall rate of major adverse cardiac events (MACE) was higher in the diabetic group (15.8% vs 11.9%).

Impact:

  • Diabetes is an independent risk factor for adverse long-term outcomes following PCI in patients with multivessel disease.
  • Increased mortality, stent thrombosis, and MACE rates in diabetics underscore the need for intensified management and tailored treatment strategies.
  • These findings emphasize the importance of considering diabetic status in risk stratification and treatment planning for multivessel coronary artery disease.
Abstract

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