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Published on: September 30, 2020

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[Assessment of prognostic and influencing factors in elderly patients with multiple organ dysfunction syndrome]

Kun Xiao1, Chao Guo, Long-xiang Su

  • 1Department of Respiratory Disease, Chinese PLA General Hospital, Beijing 100853, China.

Zhonghua Yi Xue Za Zhi
|October 16, 2013
PubMed
Abstract

Insights

Prognostic scoring systems accurately predict outcomes for patients with multiple organ dysfunction syndrome (MODSE). Higher patient age and more organ failures indicate a worse prognosis.

Area of Science:

  • Critical Care Medicine
  • Prognostic Factor Analysis
  • Clinical Outcomes Research

Context:

  • Multiple organ dysfunction syndrome (MODSE) presents a significant challenge in critical care.
  • Accurate prognosis is crucial for patient management and resource allocation.
  • Existing scoring systems require validation for diverse patient populations.

Purpose:

  • To evaluate the prognostic accuracy of four scoring systems (APACHE II, APACHE III, SAPSII, MODS) in MODSE patients.
  • To identify independent factors influencing the 28-day survival of MODSE patients.
  • To compare the predictive performance of different scoring systems.

Summary:

  • Retrospective analysis of 365 MODSE patients revealed a 28-day mortality of 45.8%.
  • Older age, increased number of organ failures, and higher scores across all evaluated systems (APACHE II, APACHE III, SAPSII, MODS) were associated with non-survival.
  • Logistic regression identified plasma albumin concentration and mean arterial pressure (MAP) as favorable prognostic factors, while age and organ failure number were unfavorable.

Impact:

  • All four scoring systems demonstrated accurate prognostic capabilities for MODSE.
  • The APACHE II system showed the best predictive power.
  • Key independent prognostic factors include plasma albumin, MAP, patient age, and the number of organ failures, guiding clinical decision-making.

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