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Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

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Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
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Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

635
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

807
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

802
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

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Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
642

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Related Experiment Video

Updated: May 7, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D in heart failure.

Anna J Meredith1, Bruce M McManus

  • 1James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

Journal of Cardiac Failure
|October 16, 2013
PubMed
Summary

Vitamin D deficiency is a cardiovascular risk factor, but current evidence is insufficient to recommend vitamin D supplements for preventing heart failure after heart injury.

Keywords:
Vitamin Dheart failureremodeling

Related Experiment Videos

Last Updated: May 7, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.3K

Area of Science:

  • Cardiology
  • Endocrinology
  • Nutritional Science

Background:

  • Growing evidence links vitamin D to cardiovascular health, with deficiency identified as a significant risk factor.
  • The human heart possesses vitamin D signaling pathways, suggesting a direct role in cardiac physiology and outcomes.
  • Myocardial remodeling is central to heart failure (HF), a condition with increasing global impact.

Purpose of the Study:

  • To critically appraise the scientific literature on vitamin D's role in cardiovascular disease.
  • To review epidemiologic, supplementation, animal model, and in vitro data.
  • To evaluate vitamin D's potential as a therapeutic adjunct for HF prevention.

Main Methods:

  • Comprehensive review and critical appraisal of existing scientific literature.
  • Analysis of epidemiologic studies, clinical supplementation trials, and preclinical research (animal models, in vitro studies).

Main Results:

  • Substantial associative data link vitamin D status to cardiovascular outcomes.
  • Evidence supports vitamin D's involvement in key pathogenic processes like cardiac hypertrophy and extracellular matrix remodeling.
  • Limited mechanistic data exist to support vitamin D supplementation for HF prevention post-myocardial injury.

Conclusions:

  • While vitamin D is associated with cardiovascular health and influences cardiac remodeling, its therapeutic role in preventing heart failure requires further mechanistic investigation.
  • Current evidence does not support vitamin D supplementation as a primary strategy for preventing heart failure following myocardial injury.