Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.8K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring the optimal GDM management in twin pregnancies-Comment on Obstetric and neonatal outcomes in the management of twin pregnancies with gestational diabetes using the IADPSG criteria for singleton pregnancies.

BMC pregnancy and childbirth·2026
Same author

Drivers of ecosystem multifunctionality in temperate forests: Carbon-biodiversity coupling in natural forests versus soil-structural control in plantations.

Journal of environmental management·2026
Same author

Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers with Overweight/Obesity and Their Offspring: An 8- to 10-Year Follow-Up Study.

Advances in therapy·2026
Same author

Long-term mortality in women with a history of hypertensive disorders of pregnancy: a systematic review and meta-analysis.

EClinicalMedicine·2026
Same author

Association of maternal longitudinal haemoglobin concentrations with adverse pregnancy outcomes: A prospective cohort study.

Journal of global health·2026
Same author

Era of Evidence-Based Medicine and the Artificial Intelligence: The Transition of Obstetric Decision-Making From Empirical to Precision-Based Approaches.

Maternal-fetal medicine (Wolters Kluwer Health, Inc.)·2026
Same journal

Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy in twin pregnancies: a systematic review and meta-analysis.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Clinical and immunological characteristics associated with adverse perinatal outcomes among pregnant people living with HIV: a retrospective cohort study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Retraction statement: rupture of the pregnant uterus - a 20-year review.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Retraction statement: a new conservative surgical approach for placenta accreta spectrum in a low-resource setting.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Response to the letter regarding "cervical length and fetal fibronectin for the identification of true spontaneous onset of labor".

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
Same journal

Paternal age and adverse pregnancy outcomes: a spline analysis from the nulliparous pregnancy outcomes study: monitoring mothers-to-be study.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

748

Gestational diabetes mellitus, programing and epigenetics.

Jie Yan1, Huixia Yang

  • 1Department of Obstetrics and Gynecology, Peking University First Hospital , Beijing , China.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|October 16, 2013
PubMed
Summary
This summary is machine-generated.

Gestational diabetes mellitus (GDM) in pregnancy can lead to higher birth weight and future metabolic disease in offspring. Epigenetic changes during development may explain these long-term health effects.

Keywords:
DNA methylationepigeneticsgestational diabetes mellitusintrauterine environmentprograming

More Related Videos

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.0K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.4K

Related Experiment Videos

Last Updated: Jan 14, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

748
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.0K
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.4K

Area of Science:

  • Reproductive biology
  • Developmental biology
  • Metabolic disease research

Background:

  • Gestational diabetes mellitus (GDM) is a common pregnancy complication.
  • Maternal hyperglycemia leads to higher offspring birth weight and increased risk of adult metabolic disease.
  • The intrauterine environment influences fetal programming, aligning with the Developmental Origins of Health and Disease (DOHaD) concept.

Purpose of the Study:

  • To review the role of epigenetic modifications in insulin resistance development.
  • To explore how adverse intrauterine exposures, like GDM, contribute to metabolic diseases via epigenetics.
  • To understand the long-term effects of in utero exposures on health.

Main Methods:

  • Review of existing literature on GDM, DOHaH, and epigenetics.
  • Analysis of studies investigating epigenetic mechanisms (e.g., DNA methylation, histone modification) in relation to intrauterine exposures.
  • Synthesis of findings on the link between epigenetic changes and insulin resistance.

Main Results:

  • Epigenetic modifications are implicated as a key mechanism in fetal programming by adverse intrauterine conditions.
  • Changes in epigenetic patterns may occur early in disease pathogenesis and progression.
  • Studies highlight the potential for epigenetic alterations to mediate long-term metabolic consequences of in utero exposures.

Conclusions:

  • Epigenetic mechanisms offer a plausible explanation for the link between adverse in utero environments and adult metabolic diseases.
  • Understanding these epigenetic changes is crucial for comprehending the long-term health impacts of maternal conditions like GDM.
  • Modulating epigenetic modifications presents a potential avenue for disease prevention and treatment strategies.