Related Experiment Video
Updated: May 7, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Association of estrogen receptor β gene polymorphisms with hypertension in postmenopausal women]
Jia-wei Xin1, Jun-jian Zhang, Ying Yang
1Zhongnan Hospital, Wuhan University, Wuhan 430071, China.
Objective:
To explore the association between estrogen receptor β (ERβ) gene polymorphisms and hypertension in postmenopausal women.
Methods:
The relationship of two polymorphisms (rs944050 and rs4986938) with hypertension was examined in 71 postmenopausal women with hypertension and 50 healthy age-matched controls.
Results:
In hypertension and control groups, the ERβ allelic frequencies of A and G were 0.500, 0.500, 0.540, 0.460; 0.077, 0.923, 0.170, 0.830 respectively. The genotypic distributions of both polymorphisms stayed within Hardy-Weinberg equilibrium. For polymorphism rs4986938, statistical difference existed between the wild-type genotype and a combination of heterozygous and homozygous variant genotypes (P < 0.05). The variant allele A of rs4986938 in ERβ gene decreased the risk of hypertension (OR = 0.41, 95%CI 0.18-0.92).
Conclusion:
The polymorphism rs4986938 in ERβ gene was associated with an elevated risk of hypertension in Chinese Han postmenopausal women.
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Hypertension II: Pathophysiology
Hormonal Regulation
Antihypertensive Drugs: Action of β1 Blockers

