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Osteoid differentiation in mesodermal (mullerian) adenosarcoma of ovary
Trupti Patel1, Anuja Gupta, Priti Trivedi
1Department of Pathology, Gujarat Cancer and Research Institute, M.P. Shah Cancer Hospital, Ahmedabad, Gujarat, India.
Journal of Cancer Research and Therapeutics
|October 16, 2013
Summary
A rare ovarian adenosarcoma with sarcomatous overgrowth was diagnosed in a 55-year-old female presenting with abdominal mass. This complex ovarian tumor requires careful pathological examination for accurate diagnosis and treatment planning.
Area of Science:
- Gynecologic Oncology
- Pathology
- Surgical Oncology
Background:
- Ovarian masses can present with diverse pathologies.
- Early and accurate diagnosis is crucial for effective management of ovarian tumors.
Observation:
- A 55-year-old female presented with a 10 cm abdominal mass and ascites.
- CT scan revealed a complex solid-cystic right ovarian mass.
- Microscopic examination showed a mix of benign/atypical Mullerian glands and sarcomatous stroma with undifferentiated cells, atypical mitoses, necrosis, and osteoid.
Findings:
- Immunohistochemistry confirmed CK-7, AE-1, and EMA positivity in the glandular component and vimentin in sarcomatous areas.
- The final diagnosis was Mullerian adenosarcoma of the ovary with sarcomatous overgrowth and a heterologous component.
- The patient received 3 cycles of postoperative chemotherapy and remained well at 3 months.
Implications:
- This case highlights the importance of thorough histopathological evaluation for diagnosing rare ovarian neoplasms.
- Aggressive surgical and chemotherapeutic management may be beneficial for ovarian adenosarcoma with sarcomatous overgrowth.
- Further research into the specific subtypes and optimal treatment strategies for such complex ovarian tumors is warranted.
