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Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

Poly(meth)acrylate-based coatings.

Kathrin Nollenberger¹, Jessica Albers

¹Evonik Industries AG, Kirschenallee, 64293 Darmstadt, Germany.

International Journal of Pharmaceutics

|October 16, 2013

Summary

This summary is machine-generated.

Poly(meth)acrylate coatings, first introduced in 1955, offer tailored drug release in the gastrointestinal tract. These versatile polymers are crucial for advanced pharmaceutical formulations and controlled drug delivery systems.

Keywords:

Coating Delayed release Poly(meth)acrylates Polymer Sustained release Taste masking

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Area of Science:

Polymer Chemistry
Pharmaceutical Sciences
Materials Science

Background:

Poly(meth)acrylate coatings, exemplified by EUDRAGIT® L and S, emerged in 1955 for pharmaceutical use.
These anionic polymers have evolved through monomer incorporation, yielding diverse forms with specific properties.
Current applications target various gastrointestinal tract regions and enable time-controlled drug release.

Purpose of the Study:

To review the properties of various poly(meth)acrylates.
To discuss formulation challenges and strategies for poly(meth)acrylate-based drug delivery systems.
To explore the application possibilities of these advanced polymer coatings in pharmaceuticals.

Main Methods:

Literature review of poly(meth)acrylate properties and applications.
Analysis of monomer incorporation effects on polymer characteristics.
Discussion of formulation considerations for gastrointestinal and time-controlled release.

Main Results:

Poly(meth)acrylates exhibit tunable properties based on their chemical composition.
Formulation strategies can optimize drug release profiles and targeting within the GI tract.
Diverse applications are feasible, ranging from enteric coatings to sustained-release systems.

Conclusions:

Poly(meth)acrylates are essential excipients for advanced pharmaceutical dosage forms.
Tailoring polymer properties through monomer selection is key to achieving desired drug delivery outcomes.
Further research into formulation and application of poly(meth)acrylates will enhance therapeutic efficacy.