Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gating current harmonics. II. Model simulations of axonal gating currents.

J F Fohlmeister, W J Adelman

    Biophysical Journal
    |September 1, 1985
    PubMed
    Summary

    This study presents a new kinetic model for sodium channel gating, analyzing gating currents using harmonic analysis. The model accurately simulates experimental data and action potential development, offering insights into gating mechanisms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    DIRECT ACCESS OF IONS TO THE SQUID STELLATE GANGLION GIANT SYNAPSE BY AORTIC PERFUSION: EFFECTS OF CALCIUM-FREE MEDIUM, LANTHANUM, AND CADMIUM.

    The Biological bulletin·2018
    Same author

    Measurement of axonal membrane conductances and capacity by means of a varying potential control voltage clamp.

    The Journal of membrane biology·2013
    Same author

    Dynamic asymmetries in the squid axon membrane.

    The Journal of general physiology·2009
    Same author

    Impulse encoding across the dendritic morphologies of retinal ganglion cells.

    Journal of neurophysiology·1999
    Same author

    Impulse encoding mechanisms of ganglion cells in the tiger salamander retina.

    Journal of neurophysiology·1997
    Same author

    Mechanisms by which cell geometry controls repetitive impulse firing in retinal ganglion cells.

    Journal of neurophysiology·1997

    Area of Science:

    • Biophysics
    • Computational Neuroscience

    Background:

    • Understanding sodium channel gating is crucial for explaining action potential dynamics.
    • Existing models like the Hodgkin-Huxley model provide a framework but may not capture all kinetic nuances.

    Purpose of the Study:

    • To develop and present a novel kinetic model for sodium activation gating.
    • To analyze gating current data using harmonic analysis to classify kinetic schemes.
    • To compare the predictive capabilities of the new model with established models.

    Main Methods:

    • Harmonic analysis of gating current data obtained from large-amplitude sinusoidal voltage clamp experiments in dynamic steady state.
    • Classification of gating kinetic schemes based on harmonic content patterns in periodic gating current records.

    Related Experiment Videos

  • Development of a kinetic model with two independently constrained processes.

    • Main Results:

    • The developed kinetic model accurately simulates experimental gating current data.
    • The model predicts specific gating current behaviors, including responses to hyperpolarizing steps and prehyperpolarized potentials.
    • It also predicts a delay in sodium ion current onset and flickering in single-channel records.
    • The model reproduces the phenomenological development of Na conductance during action potentials.

    Conclusions:

    • The new kinetic model, despite its different structure from the Hodgkin-Huxley model, effectively captures key aspects of sodium channel gating and action potential initiation.
    • The findings suggest potential gating mechanisms and provide a valuable tool for further research in channel biophysics.