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The pathogenesis of nephropathia epidemica: new knowledge and unanswered questions

Jukka Mustonen1, Satu Mäkelä, Tuula Outinen

  • 1School of Medicine, University of Tampere, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.

Antiviral Research
|October 16, 2013
PubMed

Insights

Puumala virus (PUUV) causes nephropathia epidemica (NE), a kidney disease transmitted by bank voles. This review details NE

Area of Science:

  • Infectious Diseases
  • Virology
  • Nephrology

Background:

  • Puumala virus (PUUV) causes nephropathia epidemica (NE), a zoonotic disease.
  • The bank vole (Myodes glareolus) is the primary reservoir host for PUUV.

Purpose of the Study:

  • To review the clinical manifestations of NE.
  • To discuss the pathogenesis and biomarkers of NE.
  • To explore therapeutic aspects and future research directions for NE.

Main Methods:

  • Literature review of clinical manifestations, pathogenesis, biomarkers, and therapeutics of NE.
  • Synthesis of current knowledge on PUUV infection and its effects on human health.

Main Results:

  • NE presents with acute kidney injury, increased vascular permeability, and coagulation abnormalities.
  • Pulmonary, cardiac, central nervous system, and ocular manifestations can occur.
  • Biomarkers like IL-6, PTX3, CRP, and cell-free DNA indicate disease severity.

Conclusions:

  • NE is a complex zoonotic disease with diverse clinical presentations.
  • Understanding pathogenesis and identifying biomarkers are crucial for managing NE.
  • Further research is needed to optimize NE treatment strategies.
Keywords:
HantavirusHemorrhagic fever with renal syndromeNephropathia epidemicaPuumala virus

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