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Intermediate filament structure.

R D Fraser, T P MacRae

    Bioscience Reports
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study refines models of alpha-keratin structure, suggesting 8 repeating units per filament array. This revised model better aligns with linear density estimates and explains intermediate filament lattice polymorphism.

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    Area of Science:

    • Biophysics
    • Structural Biology
    • Materials Science

    Background:

    • Previous X-ray diffraction studies indicated finite arrays of repeating units in alpha-keratin with specific axial intervals.
    • A model involving a helical dislocation was proposed to explain the observed lattice structure.

    Purpose of the Study:

    • To re-evaluate the number of repeating units in alpha-keratin filaments based on new insights into molecular interactions.
    • To develop a more compatible model for intermediate filament lattices, considering linear density and polymorphism.

    Main Methods:

    • Quantitative X-ray diffraction analysis.
    • Modeling of filament structure based on lattice parameters and molecular orientation.
    • Comparison of models with 7 versus 8 repeating units.

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    Main Results:

    • A model with 8 repeating units is more compatible with linear density estimates than a model with 7.
    • The choice of 8 repeating units provides a basis for a general model of intermediate filament lattice polymorphism.
    • New understanding of coiled-coil rope segment orientation impacts the importance of lattice mismatch minimization.

    Conclusions:

    • The revised model with 8 repeating units offers a better explanation for alpha-keratin filament structure.
    • This work contributes to a general understanding of polymorphism in intermediate filament lattices.
    • Structural models should account for molecular orientation relative to lattice dislocations.