Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Phase-tuned modulation during reward expectancy in human anterior insular cortex.

Communications biology·2026

Same author

Blood volume-sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.

Imaging neuroscience (Cambridge, Mass.)·2026

Same author

Distinct representational properties of cues and contexts shape fear and reversal learning.

eLife·2026

Same author

Cortisol treatment impairs path integration and alters grid-like representations in the male human entorhinal cortex.

PLoS biology·2026

Same author

Extinction memories: putting learning into context.

Trends in cognitive sciences·2026

Same author

Selective Attention Dynamically Modulates the Hierarchical Order of Perceptual and Conceptual Representations.

Human brain mapping·2025

Same journal

Misinformation as strategy: Epistemic consequences and the undermining of shared truth.

Trends in cognitive sciences·2026

Same journal

Geographical psychology: Spatial variation in psychological phenomena and their consequences.

Trends in cognitive sciences·2026

Same journal

Multi-brain neurofeedback: what are we training for?

Trends in cognitive sciences·2026

Same journal

The developing vocal self.

Trends in cognitive sciences·2026

Same journal

Searching beyond decrements: Attentional guidance across the adult lifespan.

Trends in cognitive sciences·2026

Same journal

Looking into working memory through micro eye movements.

Trends in cognitive sciences·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 7, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

Published on: June 2, 2018

Electrical engram: how deep brain stimulation affects memory.

Hweeling Lee¹, Jürgen Fell, Nikolai Axmacher

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Trends in Cognitive Sciences

|October 16, 2013

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) may improve memory by enhancing natural brain wave patterns, not just by inhibiting or exciting brain regions. This approach focuses on restoring normal electrophysiology for better memory function.

More Related Videos

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

Related Experiment Videos

Last Updated: May 7, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

Published on: June 2, 2018

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation

Published on: June 7, 2016

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Transcranial Direct Current Stimulation tDCS for Memory Enhancement

Published on: September 18, 2021

Area of Science:

Neuroscience
Neuromodulation
Cognitive Science

Background:

Deep brain stimulation (DBS) is a surgical treatment for neurological and psychiatric disorders.
Current DBS efficacy is often attributed to high-frequency stimulation's inhibitory or excitatory effects on targeted brain areas.
Recent research explores DBS for Alzheimer's disease to enhance memory functions.

Purpose of the Study:

To propose a novel perspective on the mechanism of action for DBS in ameliorating memory dysfunction.
To investigate how DBS might enhance normal electrophysiological patterns related to memory processes.

Main Methods:

The study proposes a theoretical framework based on existing knowledge of DBS and neurophysiology.
It focuses on the impact of repetitive electrical stimuli on extracellular field-potential oscillations.
The medial temporal lobe's role in long-term memory is considered central to the proposed mechanism.

Main Results:

DBS may not solely rely on broad inhibition or excitation.
A key mechanism could involve the enhancement of natural electrophysiological patterns crucial for memory.
This enhancement may specifically target oscillations within the medial temporal lobe.

Conclusions:

Deep brain stimulation may improve memory by modulating, rather than simply suppressing or activating, neural activity.
The findings suggest that DBS could restore physiological oscillatory patterns essential for long-term memory formation and retrieval.
This perspective opens new avenues for understanding and optimizing DBS therapy for memory deficits.