Related Experiment Video
Updated: May 7, 2026

08:25
Circumscribed Capsular Infarct Modeling Using a Photothrombotic Technique
Published on: June 2, 2016
7.3K
Pseudoperipheral palsy due to infarction in the internal capsule
Hiroki Masuda1, Shoichi Ito, Shigeyuki Kojima
1Department of Neurology, Matsudo City Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|October 16, 2013
Summary
Lacunar infarctions rarely cause pseudoperipheral palsy. This case reveals hand fiber topography in the internal capsule, linking specific infarct locations to hand movement deficits.
Area of Science:
- Neurology
- Neuroscience
- Radiology
Background:
- Pseudoperipheral palsy is typically caused by cerebral cortical infarctions.
- Lacunar infarctions, particularly in the posterior limb of the internal capsule, are an uncommon cause.
- The precise somatotopic organization of the corticospinal tract within the posterior limb of the internal capsule is not well-established.
Observation:
- An 81-year-old Japanese woman presented with a characteristic left hand drop.
- Brain magnetic resonance imaging (MRI) identified an acute lacunar infarction.
- The lesion was located in the anteromedial portion of the inferior level of the right internal capsule's posterior limb.
Findings:
- The specific location of the infarction correlated with the patient's hand motor deficit.
- This case provides direct evidence for the topographical organization of corticospinal tract fibers controlling hand movements within the internal capsule.
Implications:
- This finding helps elucidate the detailed neuroanatomy of the corticospinal tract.
- Understanding this topography can improve the diagnosis and localization of lesions causing motor impairments.
- It contributes to the understanding of lacunar stroke syndromes affecting fine motor control.
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
773
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
773
Peripheral Artery Disease I: Introduction
663
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
663
Spinal Nerves: Plexus I
3.4K
Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
3.4K
Secondary Spinal Cord Injury llI: Pathophysiology
72
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
72

