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Determinants of left ventricular hypertrophy in patients with recent diagnosis of essential hypertension

Francesco Buono1, Salvatore Crispo, Gennaro Pagano

  • 1aDipartimento di Scienze Mediche Traslazionalie, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Telese Terme bDipartimento Scienze Biomediche Avanzate, Università FEDERICO II, Napoli, Italy.

Journal of Hypertension
|October 16, 2013
PubMed

Insights

Obesity is the primary modifiable risk factor for left ventricular hypertrophy (LVH) in patients recently diagnosed with essential hypertension. Managing obesity is crucial for preventing LVH development and improving cardiovascular health.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Medicine

Background:

  • Left ventricular hypertrophy (LVH) is a complex condition influenced by multiple factors.
  • Essential hypertension is a common condition requiring assessment of associated risks.

Purpose of the Study:

  • To identify and assess cardiovascular (CV) risk factors contributing to LVH in patients newly diagnosed with essential hypertension.
  • To determine the most significant modifiable risk factor for LVH in this population.

Main Methods:

  • Retrospective analysis of 1518 patients diagnosed with essential hypertension within the last two years.
  • Evaluation of CV risk factors including age, blood pressure (SBP, DBP), obesity, diabetes, hypercholesterolemia, low HDL-cholesterol, and chronic kidney disease (CKD).

Main Results:

  • Patients with LVH exhibited higher prevalence of metabolic diseases, CKD, and more severe hypertension.
  • Multivariate analysis identified sex, age, SBP, obesity, and diabetes as independent predictors of LVH.
  • Obesity showed a significant correlation with indexed left ventricular mass (r²=0.167).

Conclusions:

  • Obesity is identified as the most critical modifiable cardiovascular risk factor for developing LVH in patients with recent-onset essential hypertension.
  • This finding underscores the importance of weight management in hypertension care to mitigate LVH risk.
Abstract

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