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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Related Experiment Video

Updated: May 6, 2026

Collection of Serum- and Feeder-free Mouse Embryonic Stem Cell-conditioned Medium for a Cell-free Approach
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Regulating aging in adult stem cells with microRNA.

M Hodzic1, Y Naaldijk, A Stolzing

  • 1University of Berlin, Berlin, Deutschland.

Zeitschrift Fur Gerontologie Und Geriatrie
|October 16, 2013
PubMed
Summary

Aging results from cellular damage and epigenetic changes, impacting stem cells and regeneration. MicroRNAs are key regulators of these processes, offering insights into age-related decline and potential interventions.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Stem Cell Biology

Background:

  • Aging is characterized by accumulated cellular damage and epigenetic deregulation.
  • These changes lead to impaired cellular maintenance, reduced tissue regeneration, immune weakening, and increased cancer risk.
  • Understanding age-related changes in adult stem cells is vital for comprehending organ and tissue deterioration.

Purpose of the Study:

  • To explore the role of microRNAs in regulating stem cell properties during aging.
  • To investigate how microRNAs influence cellular maintenance, regeneration, and senescence.
  • To highlight the relevance of microRNAs in aging research due to their regulatory functions.

Main Methods:

  • Review of current literature on aging, stem cells, and microRNA biology.

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Techniques to Induce and Quantify Cellular Senescence
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  • Analysis of microRNA-mediated regulation of cellular processes relevant to aging.
  • Identification of microRNAs involved in stem cell potency, self-renewal, differentiation, and senescence.

    • Main Results:

    • MicroRNAs are crucial posttranscriptional regulators of gene expression.
    • They co-regulate essential stem cell properties, including self-renewal, differentiation, and senescence.
    • MicroRNAs also regulate cellular defense mechanisms against oxidative stress (ROS), DNA repair, and apoptosis.

    Conclusions:

    • MicroRNAs play a significant role in the aging process by modulating stem cell behavior and cellular maintenance.
    • Their function as general regulators positions them as critical factors in age-related pathologies.
    • Further research into microRNAs could unlock new therapeutic strategies for age-related diseases.