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The heat shock response.

E A Craig

    CRC Critical Reviews in Biochemistry
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Cells activate heat shock proteins (HSPs) in response to stress, a conserved mechanism across species. These HSPs are linked to increased thermoresistance, suggesting evolutionary importance.

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    Area of Science:

    • Molecular Biology
    • Cellular Stress Response
    • Evolutionary Biology

    Background:

    • Cells activate specific genes in response to heat shock or other environmental stresses.
    • This stress response, involving heat shock proteins (HSPs), is conserved across diverse species from bacteria to animals.
    • Accumulating evidence suggests homology among HSPs in different species.

    Purpose of the Study:

    • To review and assess data on the homology of heat shock proteins across species.
    • To examine the cellular localization of heat shock proteins.
    • To investigate the relationship between heat shock proteins and thermoresistance.

    Main Methods:

    • Review of existing scientific literature on heat shock proteins.
    • Analysis of data concerning protein homology and sequence similarity.

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  • Examination of studies on protein localization within cells.
  • Correlation analysis between HSP presence and organismal thermoresistance.

    • Main Results:

    • Heat shock response is a conserved phenomenon observed in a wide range of organisms.
    • Homology exists among heat shock proteins in diverse species, indicating evolutionary conservation.
    • A positive correlation is frequently observed between the presence of HSPs and an organism's ability to withstand thermal stress.

    Conclusions:

    • The heat shock response and associated proteins are evolutionarily conserved.
    • Heat shock proteins play a crucial role in cellular thermoresistance.
    • Further research into HSP homology and function is warranted.