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Updated: May 6, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Immunosenescence and immune response in organ transplantation
Paulo Ney Aguiar Martins1, Stefan G Tullius, James F Markmann
1Division of Transplantation, Department of Surgery, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
Abstract:
The immune system undergoes a complex and continuous remodeling with aging. Immunosenescence results into both quantitative and qualitative changes of specific cellular subpopulations that have major impact on allorecognition and alloresponse, and consequently on graft rejection and tolerance. Here, we are going to review the immunological changes associated with the aging process relevant for transplantation. Interventions to selectively target changes associated with the senescence process seem promising therapeutic strategies to improve transplantation outcome.
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