Related Experiment Video
Updated: May 6, 2026

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
Published on: February 20, 2021
[Potential drug interactions in patients with sepsis admitted to the intensive care unit]
Objective:
To analyze, detect and classify potential drug interactions in patients with sepsis admitted to the intensive care unit.
Methods:
This prospective observational cohort study of septic patients was conducted between April 2010 and August 2011. Data collection included demographic characteristics, clinical features, and analysis of pharmacotherapy.
Results:
Of 86 patients, 80% had potential drug interactions, with a mean of 1.84 ± 1.09 interaction per patient. Regarding the classification of drug interactions, 64.2% had a pharmacodynamic profile, 60% were of major severity, 53.3% had a rapid onset of action, and 53.8% had good documentation. The prevalence of interactions was associated with age, number of drugs prescribed, and length of stay in the intensive care unit (p < 0.001).
Conclusion:
This study showed that drug interactions represent an important clinical concern in septic patients admitted to intensive care units.
Related Concept Videos
Pharmacokinetics: Drug–Drug Interactions
Drug toxicity: Drug–Drug Interaction
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Acute Kidney Injury V: Interprofessional Care
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

