New phenanthrene derivatives with nitric oxide inhibitory and radical-scavenging activities from Pholidota imbricata
Jue Wang1, Tiejie Wang, Pu Xie
1a Shenzhen Institute For Drug Control , Guangdong 518057 , P.R. China.
Abstract:
One new phenanthrene derivative phoimbrtol A (1) with seven known compounds, loddigesiinol B (2), shanciol B (3), (-)-medioresinol (4), (-)-pinoresinol (5), quercetin 3-O-β-L-arabinofuranoside (6), luteolin 7-O-β-glucoside (7) and platycaryanin D (8) have been isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricata Hook. Their inhibitory effects on nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity were examined. Among these compounds, 8 exhibited the most potent activity at NO production inhibitory assay and DPPH radical scavenging assay, stronger than those of the familiar antioxidative agents, quercetin and resveratrol.
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