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Published on: April 26, 2024
Morningness-eveningness and treatment response in major depressive disorder
Emmanuelle Corruble1, Ellen Frank, Florence Gressier
1Paris XI University, INSERM U 669, Department of Psychiatry, Bicêtre University Hospital , Assistance Publique - Hôpitaux de Paris, 94230 Le Kremlin Bicêtre , France .
Abstract:
In a large, prospective, 8-week open study of 721 outpatients receiving agomelatine treatment for a current major depressive episode (MDE), morningness-eveningness (Composite Scale of Morningness) was assessed before and after treatment to investigate possible changes in morningness-eveningness after treatment and evaluate whether morningness-eveningness at baseline predicted treatment response. A change towards morningness was observed after treatment. This change was greater in responders than non-responders. Moreover, being a morning type at baseline was an independent predictor of response to treatment. Once thought to be a trait variable, morningness-eveningness is a potential treatment target that should be systematically assessed in MDE patients.
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