Related Experiment Video

Updated: May 6, 2026

Transdermal Measurement of Glomerular Filtration Rate in Mice
07:25

Transdermal Measurement of Glomerular Filtration Rate in Mice

Published on: October 21, 2018

23.8K

Assessment of cystatin C and cystatin C-based GFR formulas in reflux nephropathy

Sevgi Yavuz1, Ali Anarat1, Aysun K Bayazıt1

  • 1Division of Pediatric Nephrology, Cukurova University School of Medicine, 01330 Adana, Turkey.

Journal of Pediatric Urology
|October 17, 2013
PubMed

Insights

Serum cystatin C effectively identifies reflux nephropathy (RN) risk and severity in children with vesicoureteral reflux (VUR). Combined creatinine and cystatin C formulas offer more accurate renal function assessment.

Area of Science:

  • Pediatric Nephrology
  • Biomarker Discovery

Background:

  • Reflux nephropathy (RN) is a complication of vesicoureteral reflux (VUR) that can lead to chronic kidney disease (CKD).
  • Early identification of RN is crucial for preventing CKD progression in children.

Purpose of the Study:

  • To evaluate the utility of serum cystatin C as a biomarker for detecting RN in pediatric VUR patients.
  • To compare the diagnostic value of cystatin C with serum creatinine (Scr) for assessing renal scarring.

Main Methods:

  • Serum cystatin C, Scr, and urine creatinine were measured in 93 children with VUR.
  • Patients were grouped based on the presence and grade of renal scarring (RS).
  • Estimated glomerular filtration rate (eGFR) was calculated using Scr-based, cystatin C-based, and combined formulas.

Main Results:

  • Serum cystatin C levels were significantly higher in children with RS and decreased with increasing scar severity.
  • Scr levels did not show significant differences between groups, except between mild and severe scarring.
  • All eGFR calculations were lower in patients with RS and correlated negatively with scar grade.

Conclusions:

  • Serum cystatin C is a valuable marker for identifying the risk and severity of RN in children with VUR.
  • Combined Scr-cystatin C eGFR equations provide a more accurate assessment of renal function in these patients.
Abstract

Keywords:
Cystatin CGlomerular filtration rateReflux nephropathyVesicoureteral reflux

More Related Videos

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

45.1K
Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat06:58

Physiology Lab Demonstration: Glomerular Filtration Rate in a Rat

Published on: July 26, 2015

16.8K

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
343
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
146
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
589
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
374
Renal Clearance01:23

Renal Clearance

The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
3.2K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
699