Relationship between atopy, allergic diseases and total serum IgE levels among HIV-infected children

In recent years there has been increasing prevalence of allergic diseases globally, especially in children. Many IgE-dependent allergic manifestations have been described in HIV-infected individuals. However, it seems to be controversial whether immunological changes, such as IgE elevation, results from the infection or is related to the presence of allergy in these subjects. The aim of this study was to survey the literature of articles focused on the pediatric population with HIV infection, total serum IgE and / or allergic diseases and atopy. We conducted a narrative review, from articles found in Medline and LILACS published in the last 20 years using the key words: children, allergic disease, HIV, IgE.     After eliminating duplicates in databases, 33 international articles were considered. We selected seven articles that addressed the proposed aim of study to perform a complete reading and discussing.

this review showed that high IgE levels can be found for other reasons than atopy or allergic disease in children with HIV. Specific IgE against the antigens of the HIV virus and higher levels of total serum IgE can be seen in children with or without aggravation of AIDS. Finally, we reiterate the call made by the authors of some studies for more studies on the subject, especially with larger samples in pediatric population.