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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

293
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
293
Allergic Reactions02:06

Allergic Reactions

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Overview
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

223
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
223
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: May 6, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

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Molecule-based diagnosis and allergen immunotherapy.

E Scala1

  • 1. e.scala@idi.it.

European Annals of Allergy and Clinical Immunology
|October 17, 2013
PubMed
Summary

Allergen immunotherapy (AIT) can fail due to poor diagnosis or treatment. Molecule-based diagnostics and precise allergen products improve AIT effectiveness for allergic diseases.

Area of Science:

  • Immunology
  • Allergy Research
  • Medical Diagnostics

Background:

  • Allergen immunotherapy (AIT) is the only disease-modifying treatment for allergies.
  • Treatment failures in AIT can stem from inaccurate diagnosis or suboptimal therapeutic strategies.
  • Understanding specific IgE sensitization and reliable allergen mixtures are crucial for successful AIT.

Purpose of the Study:

  • To explore the reasons behind AIT treatment failures.
  • To highlight the importance of molecule-based diagnostics for accurate IgE reactivity profiling.
  • To emphasize the need for well-defined allergen products in AIT.

Main Methods:

  • Utilizing a molecule-based diagnostic approach to evaluate patient IgE reactivity.
  • Distinguishing between genuine and panallergen-driven antigen recognition.

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  • Molecular dissection of allergen products for AIT.

    • Main Results:

    • A comprehensive IgE reactivity profile can be achieved through molecule-based diagnostics.
    • This approach helps differentiate true allergen sensitization from cross-reactivity.
    • Improved understanding of diagnostic findings and AIT products enables better treatment correlation.

    Conclusions:

    • Inadequate diagnosis and poorly defined allergen mixtures contribute to AIT failure.
    • Molecule-based diagnostics offer a precise way to assess patient sensitization.
    • Tailoring AIT using molecular insights can enhance treatment efficacy and patient outcomes.