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Updated: May 6, 2026

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
Published on: March 14, 2021
Phloretin-induced reduction in dipole potential of sterol-containing bilayers
Olga S Ostroumova1, Svetlana S Efimova, Ludmila V Schagina
1Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Ave. 4, Saint Petersburg, 194064, Russia, osostroumova@mail.ru.
Abstract:
The phloretin-induced reduction in the dipole potential of planar lipid bilayers containing cholesterol, ergosterol, stigmasterol, 7-dehydrocholesterol and 5α-androstan-3β-ol was investigated. It is shown that effects depend on the type and concentration of membrane sterol. It is supposed that the effectiveness of phloretin in reducing the dipole potential of the bilayers that contain cholesterol, ergosterol and 7-dehydrocholesterol correlates with the ordering and condensing effects. The role of the concentration-dependent ability of different sterols to promote lateral heterogeneity in membranes is also discussed.
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